The objective of the research work was to formulate and optimize the oral sustained release matrix tablets containing tramadol hydrochloride by 32 factorial design. Matrix tablets were prepared by wet granulation method using HPMC K15M as matrixing agent. Polynomial equations and response surface plots were generated for all dependent variables using multiple regression analysis. It was observed that both the factors had significant influence on all dependent variables studied (p<0.05). The results indicating that as the concentration of polymer increases the release rate constant was decreased. Release rate obtained was highest when lactose was employed as filler followed by dicalcium phosphate and starch. In initial stage both concentration of polymer and type of filler governed the drug release while in later stage only concentration of polymer predominates. Hence, major controlling factor for kinetics of drug release was concentration of polymer.
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